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Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene

Human pluripotent stem cells (hPSCs) hold great promise for here cell therapy.However, a major concern is the risk of tumor formation by residual undifferentiated cells contaminating the hPSC-derived cell product.Suicide genes could safeguard against such adverse events by enabling elimination of cells gone astray, but the efficacy of this approach

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